Recombinant Topoisomerase I 抗体 (full length)
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Quick Overview for Recombinant Topoisomerase I 抗体 (full length) (ABIN7879154)
抗原
See all Topoisomerase I (TOP1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- Recombinant DNA topoisomerase I Antibody / TOP1MT
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human TOP1MT protein was used as the immunogen for the recombinant DNA topoisomerase I antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the recombinant DNA topoisomerase I antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant DNA topoisomerase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
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别名
- DNA topoisomerase I
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背景
- DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
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UniProt
- Q969P6
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途径
- Caspase Cascade in Apoptosis, Stem Cell Maintenance
抗原
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