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Recombinant Topoisomerase I 抗体 (full length)

This 小鼠 单克隆 antibody specifically detects Topoisomerase I in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7879154
发货至: 中国
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Quick Overview for Recombinant Topoisomerase I 抗体 (full length) (ABIN7879154)

抗原

See all Topoisomerase I (TOP1) 抗体
Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

抗体类型

Recombinant Antibody

适用

  • 82
  • 41
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  • 3
  • 3
  • 2
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  • 1
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  • 1

宿主

  • 66
  • 14
  • 2
小鼠

克隆类型

  • 43
  • 39
单克隆

标记

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  • 1
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This Topoisomerase I antibody is un-conjugated

应用范围

  • 57
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  • 10
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  • 2
  • 1
  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RTOP1MT-488
  • 抗原表位

    • 11
    • 8
    • 5
    • 3
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    • 2
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length

    原理

    Recombinant DNA topoisomerase I Antibody / TOP1MT

    纯化方法

    Protein A/G affinity

    免疫原

    Recombinant full-length human TOP1MT protein was used as the immunogen for the recombinant DNA topoisomerase I antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the recombinant DNA topoisomerase I antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the recombinant DNA topoisomerase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

    别名

    DNA topoisomerase I

    背景

    DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

    UniProt

    Q969P6

    途径

    Caspase Cascade in Apoptosis, Stem Cell Maintenance
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