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Recombinant Topoisomerase I 抗体 (full length)

The 小鼠 单克隆 anti-Topoisomerase I antibody (Clone rTOP1MT-488) (ABIN7879153) specifically detects Topoisomerase I in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7879153
发货至: 中国
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Quick Overview for Recombinant Topoisomerase I 抗体 (full length) (ABIN7879153)

抗原

See all Topoisomerase I (TOP1) 抗体
Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

抗体类型

Recombinant Antibody

适用

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宿主

  • 66
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小鼠

克隆类型

  • 43
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单克隆

标记

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This Topoisomerase I antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

RTOP1MT-488
  • 抗原表位

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    full length

    原理

    Recombinant DNA topoisomerase I Antibody / TOP1MT (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    Recombinant full-length human TOP1MT protein was used as the immunogen for the recombinant DNA topoisomerase I antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the recombinant DNA topoisomerase I antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the recombinant DNA topoisomerase I antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))

    别名

    DNA topoisomerase I

    背景

    DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

    UniProt

    Q969P6

    途径

    Caspase Cascade in Apoptosis, Stem Cell Maintenance
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