Recombinant TCP1 alpha/CCTA 抗体 (full length)
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Quick Overview for Recombinant TCP1 alpha/CCTA 抗体 (full length) (ABIN7879123)
抗原
See all TCP1 alpha/CCTA (TCP1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Recombinant p63 Antibody / Rabbit Monoclonal (azide and preservative free)
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纯化方法
- Protein A affinity chromatography
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免疫原
- Full-length human recombinant protein was used as the immunogen for the recombinant TP63 antibody.
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亚型
- IgG, kappa
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anti-T-Complex 1 (TCP1) (AA 1-556) antibody
TCP1 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2B2-D6 unconjugated
anti-T-Complex 1 (TCP1) (C-Term) antibodyVerified TCP1 适用: 人 WB, IHC, FACS, IF, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-T-Complex 1 (TCP1) (C-Term) antibodyTCP1 适用: 人 WB, IHC, FACS, IF, ICC 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-T-Complex 1 (TCP1) (AA 82-98) antibodyTCP1 适用: 人, 小鼠, 大鼠 WB, FACS, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-T-Complex 1 (TCP1) (C-Term) antibody (Atto 594)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a Atto 594
anti-T-Complex 1 (TCP1) (C-Term) antibody (Atto 390)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a Atto 390
anti-T-Complex 1 (TCP1) (C-Term) antibody (Atto 488)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a Atto 488
anti-T-Complex 1 (TCP1) (C-Term) antibody (Biotin)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a Biotin
anti-T-Complex 1 (TCP1) (C-Term) antibody (FITC)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a FITC
anti-T-Complex 1 (TCP1) (C-Term) antibody (APC)TCP1 适用: 小鼠 WB, FACS, IF, IP, ICC 宿主: 大鼠 Monoclonal 91a APC
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应用备注
- The stated application concentrations are suggested starting points. Titration of the recombinant TP63 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant TP63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))
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别名
- p63
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背景
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TP63 antibody (clone TMPR63-1R) is a recombinantly produced mAb that targets Tumor protein 63, a nuclear transcription factor encoded by the TP63 gene and a member of the p53 protein family. Tumor protein 63 is predominantly localized to the nucleus of epithelial cells, where it regulates gene expression programs required for epithelial development, differentiation, and tissue homeostasis. TP63 is highly expressed in basal and progenitor cell layers of stratified epithelia, including epidermis, prostate, urothelium, and respiratory epithelium, making it a widely used marker of basal epithelial cell populations.
Functionally, Tumor protein 63 controls epithelial stem cell maintenance and lineage commitment by regulating genes involved in proliferation, adhesion, and differentiation. A short functional summary is that TP63 preserves epithelial integrity and regenerative capacity by maintaining basal cell identity. Through alternative promoter usage and splicing, TP63 gives rise to multiple isoforms with distinct transcriptional activities that fine tune epithelial growth and differentiation programs.
At the molecular level, Tumor protein 63 contains a central DNA binding domain, an oligomerization domain, and variable N-terminal and C-terminal regions that determine transcriptional activity. These structural features allow TP63 to form tetramers and interact with DNA regulatory elements and co-factors. TP63 antibody reagents are commonly used to examine nuclear expression patterns, isoform distribution, and changes in epithelial differentiation status in normal and diseased tissues.
From a biological and disease relevance perspective, TP63 is an established diagnostic marker in pathology, particularly for identifying basal cells in prostate tissue and distinguishing squamous and myoepithelial tumors from other malignancies. Altered expression or imbalance of Tumor protein 63 isoforms has been associated with cancer progression, epithelial dysplasia, and developmental disorders affecting ectoderm derived tissues. TP63 antibody tools are therefore valuable in studies of cancer biology, epithelial differentiation, and tissue architecture.
Developmentally, TP63 expression is essential for stratified epithelial formation and organogenesis. Loss of TP63 function disrupts epithelial integrity and regenerative capacity. TP63 antibodies from NSJ Bioreagents, including clone TMPR63-1R, are supplied for research use to support investigations in cell biology, pathology, and translational epithelial research. -
UniProt
- Q9H3D4
抗原
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