SATB1 抗体 (full length)
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北京 101111
Quick Overview for SATB1 抗体 (full length) (ABIN7878975)
抗原
See all SATB1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- SATB1 Antibody / Special AT-rich sequence-binding protein 1
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human SATB1 protein was used as the immunogen for the SATB1 antibody.
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亚型
- IgG1
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应用备注
- Optimal dilution of the SATB1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the SATB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- SATB1 (SATB Homeobox 1 (SATB1))
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别名
- SATB1
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背景
- The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.
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UniProt
- Q01826
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途径
- Caspase Cascade in Apoptosis, Activated T Cell Proliferation
抗原
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