Recombinant Retinoblastoma Protein (Rb) 抗体 (full length)
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Quick Overview for Recombinant Retinoblastoma Protein (Rb) 抗体 (full length) (ABIN7878913)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- Recombinant Retinoblastoma Antibody
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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别名
- Retinoblastoma
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背景
- Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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