POLE3 抗体 (full length)
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北京 101111
Quick Overview for POLE3 抗体 (full length) (ABIN7878830)
抗原
See all POLE3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- POLE3 Antibody / CHRAC17
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human DNA polymerase epsilon subunit 3 protein was used as the immunogen for the POLE3 antibody.
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亚型
- IgG1
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anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (AA 1-147) antibody
POLE3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (AA 97-147) antibodyPOLE3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (AA 5-34), (N-Term) antibodyPOLE3 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB18580 unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (C-Term) antibodyPOLE3 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 猴, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (N-Term) antibodyPOLE3 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 斑马鱼, 马, 兔, 猴, Hamster, Pig, Bat, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (AA 97-147) antibodyPOLE3 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) (AA 1-147) antibodyPOLE3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) antibodyPOLE3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3) antibodyPOLE3 适用: 人, 小鼠, 猴 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal 3C5-1 unconjugated
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应用备注
- Optimal dilution of the POLE3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze-thaw cycles
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储存条件
- -20 °C
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储存方法
- Aliquot the POLE3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- POLE3 (Polymerase (DNA Directed), epsilon 3 (p17 Subunit) (POLE3))
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别名
- POLE3
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背景
- DNA replication is initiated by the binding of initiation factors to the origin of replication. Nucleosomes inhibit access to the replication machinery at these origin sequences. Nucleosome remodeling factors increase the accessibility of nucleosomal DNA to transcriptional regulators. CHRAC15 and CHRAC17 are subunits of the nucleosomal remodeling factor CHRAC (chromatin accessibility complex), which increases the accessibility of nucleosomal DNA in an ATP-dependent manner. Unlike other known chromatin remodeling factors, CHRAC also functions during chromatin assembly by using ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing. This conversion process occurs when CHRAC organizes randomly deposited histones into a regularly spaced array. In the presence of CHRAC, the nucleosomal ATPase ISWI catalyzes several ATP-dependent transitions of chromatin structure.
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UniProt
- Q9NRF9
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途径
- DNA Damage Repair
抗原
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