Recombinant Involucrin 抗体 (full length)
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Quick Overview for Recombinant Involucrin 抗体 (full length) (ABIN7878462)
抗原
See all Involucrin (IVL) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Recombinant IVL Antibody / Involucrin (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant human full-length Involucrin protein was used as the immunogen for the recombinant IVL antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the recombinant IVL antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant IVL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Involucrin (IVL)
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别名
- IVL
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背景
- It recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. It stains the involucrin in a variety of sizes: 170 kDa in MCF-7 cells, a doublet of ~115 kDa and 150 kDa in gorilla and owl monkey, 66 kDa in dog, and a doublet of 105 kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal, expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
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UniProt
- P07476
抗原
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