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Recombinant Involucrin 抗体 (full length)

The 小鼠 单克隆 anti-Involucrin antibody (Clone rIVRN-827) (ABIN7878460) specifically detects Involucrin in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7878460
发货至: 中国
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Quick Overview for Recombinant Involucrin 抗体 (full length) (ABIN7878460)

抗原

See all Involucrin (IVL) 抗体
Involucrin (IVL)

抗体类型

Recombinant Antibody

适用

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宿主

  • 86
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小鼠

克隆类型

  • 87
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单克隆

标记

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This Involucrin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

RIVRN-827
  • 抗原表位

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    full length

    原理

    Recombinant Involucrin Antibody (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    A recombinant human full-length Involucrin protein was used as the immunogen for this recombinant Involucrin antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the recombinant Involucrin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant Involucrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Involucrin (IVL)

    别名

    Involucrin

    背景

    It recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. It stains the involucrin in a variety of sizes: 170 kDa in MCF-7 cells, a doublet of ~115 kDa and 150 kDa in gorilla and owl monkey, 66 kDa in dog, and a doublet of 105 kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal, expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

    UniProt

    P07476
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