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IRF3 抗体 (full length)

This 小鼠 单克隆 antibody specifically detects IRF3 in FACS 和 IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7878449
发货至: 中国
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Room 801-803
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Quick Overview for IRF3 抗体 (full length) (ABIN7878449)

抗原

See all IRF3 抗体
IRF3 (Interferon Regulatory Factor 3 (IRF3))

适用

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宿主

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  • 52
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小鼠

克隆类型

  • 131
  • 94
单克隆

标记

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This IRF3 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

PCRP-IRF3-4D7
  • 抗原表位

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    full length

    原理

    Interferon regulatory factor 3 Antibody / IRF3

    纯化方法

    Protein A/G affinity

    免疫原

    Recombinant full-length human IRF3 protein was used as the immunogen for the Interferon regulatory factor 3 antibody.

    亚型

    IgG1
  • 应用备注

    Optimal dilution of the Interferon regulatory factor 3 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Interferon regulatory factor 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    IRF3 (Interferon Regulatory Factor 3 (IRF3))

    别名

    Interferon regulatory factor 3

    背景

    Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-Alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-Alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gammap48 and IFN consensus sequence-binding protein (ICSBP).

    UniProt

    Q14653

    途径

    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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