IRF3 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for IRF3 抗体 (full length) (ABIN7878449)
抗原
See all IRF3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- full length
-
原理
- Interferon regulatory factor 3 Antibody / IRF3
-
纯化方法
- Protein A/G affinity
-
免疫原
- Recombinant full-length human IRF3 protein was used as the immunogen for the Interferon regulatory factor 3 antibody.
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal dilution of the Interferon regulatory factor 3 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the Interferon regulatory factor 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
-
别名
- Interferon regulatory factor 3
-
背景
- Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-Alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-Alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gammap48 and IFN consensus sequence-binding protein (ICSBP).
-
UniProt
- Q14653
-
途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
抗原
-