GRAMD4 抗体 (full length)
The 小鼠 单克隆 anti-GRAMD4 antibody is suitable to detect GRAMD4 in samples from 人. It has been validated for FACS 和 IF.
产品编号 ABIN7878318
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for GRAMD4 抗体 (full length) (ABIN7878318)
抗原
See all GRAMD4 抗体
GRAMD4
(GRAM Domain Containing 4 (GRAMD4))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This GRAMD4 antibody is un-conjugated
应用范围
Flow Cytometry (FACS), Immunofluorescence (IF)
质量等级
Carrier-free
克隆位点
PCRP-GRAMD4-1A10
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抗原表位
- full length
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原理
- GRAMD4 Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Recombinant full-length human GRAMD4 protein was used as the immunogen for the GRAMD4 antibody.
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亚型
- IgG1
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anti-GRAM Domain Containing 4 (GRAMD4) (AA 23-161) antibody
GRAMD4 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GRAMD4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot the GRAMD4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
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别名
- GRAMD4
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背景
- The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
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UniProt
- Q6IC98
抗原
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