GRAMD4 抗体
GRAMD4
适用: 人
IF, FACS
宿主: 小鼠
Monoclonal
unconjugated
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- 抗原 See all GRAMD4 抗体
- GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GRAMD4 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Flow Cytometry (FACS)
- 特异性
- The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
- 交叉反应 （详细）
- Human. Predicted to react in Rat.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human GRAMD4 protein
- 亚型
- IgG1
- Top Product
- Discover our top product GRAMD4 Primary Antibody
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anti-GRAM Domain Containing 4 (GRAMD4) (AA 23-161) antibody
GRAMD4 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: Human liver, heart or fetal brain.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- GRAMD4 (GRAM Domain Containing 4 (GRAMD4))
- 别名
- GRAMD4 (GRAMD4 产品)
- 别名
- DIP antibody, dA59H18.1 antibody, dJ439F8.1 antibody, 9930016O13 antibody, dip antibody, GRAM domain containing 4 antibody, GRAM domain containing 4 S homeolog antibody, GRAMD4 antibody, Gramd4 antibody, gramd4.S antibody
- 背景
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Death-inducing protein, GRAM domain-containing protein 4 (GRAMD4),GRAMD4 (Transcription Factor)
Cellular localisation: Mitochondrion membrane. Colocalizes with COX4I1. - 分子量
- 66kDa
- 基因ID
- 23151, 475150
- UniProt
- Q6IC98
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