DMC1 抗体 (full length)
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北京 101111
Quick Overview for DMC1 抗体 (full length) (ABIN7878143)
抗原
See all DMC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- DMC1 Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant full-length human protein was used as the immunogen for the DMC1 antibody.
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亚型
- IgG2a, kappa
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anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibody
DMC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IF 宿主: 小鼠 Monoclonal 2H12-4 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 5-153) antibodyDMC1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Center) antibodyDMC1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-30), (N-Term) antibodyDMC1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23872 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 36-283) antibodyDMC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibodyDMC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Internal Region) antibodyDMC1 适用: 人, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-260) antibodyDMC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DMC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the DMC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- DMC1 (DNA Meiotic Recombinase 1 (DMC1))
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别名
- DMC1
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背景
- DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1 (Meiotic recombination protein DMC1/LIM15 homolog). Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
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UniProt
- Q14565
抗原
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