DMC1 抗体
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- 抗原 See all DMC1 抗体
- DMC1 (DNA Meiotic Recombinase 1 (DMC1))
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适用
- 人, 小鼠, 大鼠, Cow
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This DMC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length human DMC1 protein.
- 克隆位点
- 2H12-4
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product DMC1 Primary Antibody
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anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibody
DMC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 5-153) antibodyDMC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Center) antibodyDMC1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 237-339) antibodyDMC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (Internal Region) antibodyDMC1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) antibodyDMC1 适用: 人 WB 宿主: 小鼠 Monoclonal 1D12-4 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-260) antibodyDMC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-30), (N-Term) antibodyDMC1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23872 unconjugated
anti-DNA Meiotic Recombinase 1 (DMC1) (AA 1-30), (N-Term) antibodyDMC1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: HeLa cells. Cervix or prostate.
Known Application: Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- DMC1 (DNA Meiotic Recombinase 1 (DMC1))
- 别名
- DMC1 (DMC1 产品)
- 别名
- DMC1 antibody, zgc:136628 antibody, Dmc1h antibody, Lim15 antibody, Mei11 antibody, sgdp antibody, DCM1 antibody, DMC1H antibody, LIM15 antibody, dJ199H16.1 antibody, DNA meiotic recombinase 1 antibody, DMC1 antibody, dmc1 antibody, Dmc1 antibody
- 背景
- DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
- 分子量
- 37kDa
- 基因ID
- 11144
- UniProt
- Q14565
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