Chp2 抗体 (full length)
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北京 101111
Quick Overview for Chp2 抗体 (full length) (ABIN7877978)
抗原
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- CHP2 Antibody / Calcineurin B homologous protein 2 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant human full-length protein was used as the immunogen for the CHP2 antibody.
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亚型
- IgG2c, kappa
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anti-Chp2 antibody
适用: 人 WB, IF, IHC 宿主: 小鼠 Monoclonal CPTC-CHP2-1 unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, IF, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (AA 101-150) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Center) antibody适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the CHP2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the CHP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- Chp2
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背景
- CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
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UniProt
- O43745
抗原
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