Recombinant beta Catenin 抗体 (full length)
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Quick Overview for Recombinant beta Catenin 抗体 (full length) (ABIN7877828)
抗原
See all beta Catenin (CATNB) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Recombinant Beta Catenin Antibody (azide and preservative free)
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纯化方法
- Protein A affinity
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免疫原
- Recombinant full-length human Beta Catenin protein was used as the immunogen for the recombinant Beta Catenin antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant Beta Catenin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Beta Catenin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- Beta Catenin
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背景
- Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
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UniProt
- P35222
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途径
- Peptide Hormone Metabolism
抗原
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