Recombinant N-Cadherin 抗体 (full length)
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Quick Overview for Recombinant N-Cadherin 抗体 (full length) (ABIN7877743)
抗原
See all N-Cadherin (CDH2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- Recombinant N-Cadherin Antibody / CDH2 / CD325 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant full-length human protein was used as the immunogen for the recombinant N-Cadherin antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the recombinant N-Cadherin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant N-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- N-Cadherin (CDH2) (Cadherin 2 (CDH2))
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别名
- N-Cadherin
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背景
- Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325 and CDH2. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.
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UniProt
- P19022
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途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
抗原
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