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Recombinant N-Cadherin 抗体 (full length)

The 兔 单克隆 anti-N-Cadherin antibody is suitable to detect N-Cadherin in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7877742
发货至: 中国
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北京 101111
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Room 801-803
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Quick Overview for Recombinant N-Cadherin 抗体 (full length) (ABIN7877742)

抗原

See all N-Cadherin (CDH2) 抗体
N-Cadherin (CDH2) (Cadherin 2 (CDH2))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This N-Cadherin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

CDH2-3874R
  • 抗原表位

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    full length

    原理

    Recombinant CDH2 Antibody / N-Cadherin / CD325

    纯化方法

    Protein A affinity chromatography

    免疫原

    Recombinant full-length human protein was used as the immunogen for the recombinant CDH2 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the recombinant CDH2 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the recombinant CDH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    N-Cadherin (CDH2) (Cadherin 2 (CDH2))

    别名

    CDH2

    背景

    Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325 and CDH2. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

    UniProt

    P19022

    途径

    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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