OGG1 抗体 (full length)
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北京 101111
Quick Overview for OGG1 抗体 (full length) (ABIN7877599)
抗原
See all OGG1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- full length
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原理
- OGG1 Antibody / 8-Oxoguanine DNA Glycosylase
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant full-length human protein was used as the immunogen for this OGG1 antibody.
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亚型
- IgG2c, kappa
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anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-100), (N-Term) antibody
OGG1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IP, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 31-345) antibodyOGG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 151-250) antibodyOGG1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-345) antibodyOGG1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) antibodyOGG1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibodyVerified OGG1 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) antibodyOGG1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal CPTC-OGG1-1 unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 318-345), (C-Term) antibodyOGG1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB21522 unconjugated
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应用备注
- Optimal dilution of the OGG1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the OGG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
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别名
- OGG1
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背景
- 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma.
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UniProt
- O15527
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途径
- DNA Damage Repair
抗原
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