BTLA 抗体 (Extracellular)
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Quick Overview for BTLA 抗体 (Extracellular) (ABIN7877534)
抗原
See all BTLA 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- Extracellular
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原理
- BTLA Antibody / CD272 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the BTLA antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the BTLA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- BTLA (B and T Lymphocyte Associated (BTLA))
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别名
- BTLA
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背景
- B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
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UniProt
- Q7Z6A9
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途径
- Cancer Immune Checkpoints
抗原
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