FAT1 抗体 (Cytoplasmic Domain)
Our Local Distributor
北京 101111
Quick Overview for FAT1 抗体 (Cytoplasmic Domain) (ABIN7877531)
抗原
See all FAT1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
抗原表位
- Cytoplasmic Domain
-
原理
- FAT1 Antibody (Drosophila melanogaster) (azide and preservative free)
-
纯化方法
- PEG precipitation
-
免疫原
- The cytoplasmic domain of Drosophila Fat protein was used as the immunogen for the FAT1 antibody.
-
亚型
- IgM, kappa
-
-
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (AA 4450-4500) antibody
FAT1 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 4C9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (AA 4203-4539) antibodyFAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1634CT464-1-9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (Cytoplasmic Domain) antibodyFAT1 适用: Drosophila melanogaster ELISA, WB, IF 宿主: 小鼠 Monoclonal FAT1-3D7-1 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (AA 4484-4534) antibodyFAT1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the FAT1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store the FAT1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
-
-
- FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
-
别名
- FAT1
-
背景
- The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.
-
UniProt
- Q14517
抗原
-
