FAT1 抗体 (Cytoplasmic Domain)
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- 抗原 See all FAT1 抗体
- FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
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抗原表位
- Cytoplasmic Domain
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适用
- Drosophila melanogaster
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FAT1 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Coating (Coat)
- 交叉反应 （详细）
- Expected to cross-react with Chimpanzee. Rat (92 % . 85 % identity with immunogen. respectively) due to sequence homology.
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Cytoplasmic domain of Drosophila Fat protein.
- 克隆位点
- FAT1-3D7-1
- 亚型
- IgM kappa
- Top Product
- Discover our top product FAT1 Primary Antibody
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anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibody
FAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 4C9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) (AA 4203-4539) antibodyFAT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1634CT464-1-9 unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-FAT Tumor Suppressor Homolog 1 (FAT1) antibodyFAT1 适用: 人 WB, IF/ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: Wild type imaginal discs from third instar Drosophila larvae.
Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))
- 别名
- FAT1 (FAT1 产品)
- 别名
- CDHF7 antibody, CDHR8 antibody, FAT antibody, ME5 antibody, hFat1 antibody, Fath antibody, mFat1 antibody, AU023433 antibody, 2310038E12Rik antibody, FAT1 antibody, FAT atypical cadherin 1 antibody, FAT tumor suppressor homolog 1 (Drosophila) antibody, protocadherin Fat 1 antibody, FAT1 antibody, Fat1 antibody, LOC100175143 antibody, fat1 antibody
- 背景
- The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.
- 分子量
- 500kDa
- 基因ID
- 2195
- UniProt
- Q14517
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