HSPA6 抗体 (C-Term)
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Quick Overview for HSPA6 抗体 (C-Term) (ABIN7877394)
抗原
See all HSPA6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- HSPA6 Antibody / Heat shock 70 kDa protein 6
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human HSPA6 was used as the immunogen for the HSPA6 antibody.
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亚型
- IgG
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anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (AA 516-643) antibody
HSPA6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (AA 544-571), (C-Term) antibodyHSPA6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22779 unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) antibodyHSPA6 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) antibodyHSPA6 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (AA 474-643) antibodyHSPA6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (Center) antibodyHSPA6 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (AA 1-387) antibodyHSPA6 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) antibodyHSPA6 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) antibodyHSPA6 适用: 人 WB, FACS, IF 宿主: 小鼠 Monoclonal 1H3 unconjugated
anti-Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6) (AA 544-643) antibodyHSPA6 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H7 unconjugated
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应用备注
- Optimal dilution of the HSPA6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the HSPA6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B') (HSPA6))
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别名
- HSPA6
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背景
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HSPA6 antibody detects Heat shock 70 kDa protein 6, a stress-inducible molecular chaperone that belongs to the HSP70 family of heat shock proteins. The UniProt recommended name is Heat shock 70 kDa protein 6 (HSPA6). This protein is rapidly upregulated in response to heat shock, oxidative stress, and heavy metal exposure, where it assists in refolding denatured proteins and protecting cells from proteotoxic damage.
Functionally, HSPA6 antibody identifies a 646-amino-acid cytoplasmic and nuclear chaperone that binds unfolded or misfolded polypeptides to prevent aggregation and promote refolding. HSPA6 operates through an ATP-dependent mechanism, alternating between substrate-binding and release cycles coordinated by its nucleotide-binding and substrate-binding domains. Unlike constitutive HSP70 family members, HSPA6 expression is strictly inducible and transient, making it a sensitive marker of acute cellular stress. It cooperates with co-chaperones such as HSP40 and nucleotide exchange factors to restore proteostasis during recovery from stress.
The HSPA6 gene is located on chromosome 1q23.3 and is transcriptionally regulated by heat shock factor 1 (HSF1). Expression is strongly induced by thermal stress and other cytotoxic insults in epithelial, neuronal, and endothelial cells. Under normal physiological conditions, HSPA6 levels are low or undetectable, but during stress, it rapidly accumulates in both the cytoplasm and nucleus, where it stabilizes denatured proteins and facilitates their refolding or degradation.
Pathologically, HSPA6 has been implicated in neuroprotection, cardiac stress response, and cancer cell survival. Upregulation in neurons protects against protein misfolding diseases such as Alzheimer's and Parkinson's, while elevated expression in tumors may contribute to resistance against apoptosis and chemotherapy. In cardiac tissues, HSPA6 supports survival under ischemic or oxidative stress conditions. Research using HSPA6 antibody supports studies in proteostasis, cellular stress pathways, and molecular chaperone biology.
HSPA6 antibody is validated for use in relevant research applications to detect inducible heat shock proteins and examine cellular responses to thermal or oxidative stress. NSJ Bioreagents provides HSPA6 antibody reagents optimized for studies in protein folding, stress signaling, and chaperone-mediated cytoprotection. -
UniProt
- P17066
抗原
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