SNX27 抗体 (AA 96-541)
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Quick Overview for SNX27 抗体 (AA 96-541) (ABIN7877254)
抗原
See all SNX27 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 96-541
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原理
- SNX27 Antibody / Sorting nexin-27
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SNX27 recombinant protein (Position: R96-T541) was used as the immunogen for the SNX27 antibody.
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亚型
- IgG
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anti-Sorting Nexin 27 (SNX27) (AA 458-497) antibody
SNX27 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 27 (SNX27) (AA 125-175) antibodySNX27 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 27 (SNX27) (AA 313-340) antibodySNX27 适用: 人 WB 宿主: 兔 Polyclonal RB22263 unconjugated
anti-Sorting Nexin 27 (SNX27) (C-Term) antibodySNX27 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SNX27 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SNX27 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SNX27 (Sorting Nexin 27 (SNX27))
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别名
- SNX27
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背景
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SNX27 antibody detects Sorting nexin-27, encoded by the SNX27 gene on chromosome 1q21.1. SNX27 antibody is widely used in studies of endosomal trafficking, receptor recycling, and neurological disorders. Sorting nexins are a diverse family of endosomal proteins characterized by PX domains that bind phosphoinositides. SNX27 is unique among sorting nexins in containing a PDZ domain, which recognizes PDZ-binding motifs in target proteins, and an FERM-like domain, which regulates interactions with cytoskeletal and signaling proteins. This structural versatility enables SNX27 to link endosomal sorting with cell signaling and polarity.
Structurally, SNX27 is a ~61 kDa protein containing three functional domains: an N-terminal PDZ domain, a central PX domain, and a C-terminal FERM-like domain. The PX domain mediates binding to phosphatidylinositol-3-phosphate in endosomal membranes, targeting SNX27 to recycling endosomes. The PDZ domain recognizes a wide variety of membrane proteins with C-terminal PDZ-binding motifs, including receptors, transporters, and channels.
Functionally, SNX27 promotes endosome-to-plasma membrane recycling of nutrient transporters, GPCRs, and signaling receptors. This ensures surface availability of proteins like glucose transporters (GLUT1), beta-adrenergic receptors, and NMDA receptors, which are essential for metabolism, neurotransmission, and signaling. SNX27 works within the retromer complex to mediate cargo selection and retrieval. Loss of SNX27 impairs receptor recycling, leading to reduced nutrient uptake and signaling defects. Researchers employ SNX27 antibody to study receptor trafficking, endosome biology, and neurological disease mechanisms.
Clinically, SNX27 dysfunction is associated with Down syndrome, neurodevelopmental delay, and epilepsy. Reduced SNX27 expression contributes to synaptic dysfunction and impaired glutamate receptor recycling in Down syndrome models. Its broad role in trafficking links it to metabolic disease, immunity, and cancer, where altered receptor localization influences signaling outcomes. NSJ Bioreagents provides SNX27 antibody to support neuroscience, immunology, and cell biology research.
Experimentally, SNX27 antibody is applied in western blotting to detect the ~61 kDa protein, in immunofluorescence microscopy to study endosomal distribution, and in immunohistochemistry to examine tissue-specific patterns. Co-immunoprecipitation with SNX27 antibody identifies PDZ-binding cargo proteins and retromer complex partners. -
UniProt
- Q96L92
抗原
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