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Aurora Kinase B 抗体 (AA 89-251)

The 小鼠 单克隆 anti-Aurora Kinase B antibody is suitable to detect Aurora Kinase B in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7877049
发货至: 中国
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Quick Overview for Aurora Kinase B 抗体 (AA 89-251) (ABIN7877049)

抗原

See all Aurora Kinase B (AURKB) 抗体
Aurora Kinase B (AURKB)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Aurora Kinase B antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

AURKB-1845
  • 抗原表位

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    AA 89-251

    原理

    Aurora B Antibody / AURKB (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    A recombinant human protein fragment (amino acids 89-251) was used as the immunogen for this Aurora B antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the Aurora B antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the Aurora B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Aurora Kinase B (AURKB)

    别名

    Aurora B

    背景

    Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

    UniProt

    Q96GD4

    途径

    TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades
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