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Recombinant INSM1 抗体 (AA 81-125)

The 小鼠 单克隆 anti-INSM1 antibody (Clone rINSM1-6287) (ABIN7876888) specifically detects INSM1 in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7876888
发货至: 中国
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Quick Overview for Recombinant INSM1 抗体 (AA 81-125) (ABIN7876888)

抗原

See all INSM1 抗体
INSM1 (Insulinoma-Associated 1 (INSM1))

抗体类型

Recombinant Antibody

适用

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宿主

  • 36
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小鼠

克隆类型

  • 21
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单克隆

标记

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This INSM1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

RINSM1-6287
  • 抗原表位

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    AA 81-125

    原理

    INSM1 Antibody / Insulinoma associated protein 1 (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant partial protein sequence (within amino acids 81-125) from the human protein was used as the immunogen for the INSM1 antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the INSM1 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the INSM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    INSM1 (Insulinoma-Associated 1 (INSM1))

    别名

    INSM1

    背景

    Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

    UniProt

    Q01101
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