Recombinant INSM1 抗体 (N-Term)
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Quick Overview for Recombinant INSM1 抗体 (N-Term) (ABIN7126595)
抗原
See all INSM1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 81-125, N-Term
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原理
- Recombinant INSM1 (Pan-Neuroendocrine Marker) Antibody
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特异性
- Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.
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交叉反应 （详细）
- Human.
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纯化方法
- 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.
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免疫原
- Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1
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亚型
- IgG, kappa
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anti-Insulinoma-Associated 1 (INSM1) (AA 81-125), (N-Term) antibody
INSM1 适用: 人 IHC 宿主: 兔 Monoclonal 456R unconjugated Recombinant Antibody
anti-Insulinoma-Associated 1 (INSM1) (AA 75-125) antibodyINSM1 适用: 人, 小鼠 WB, IHC, ICC 宿主: 兔 Monoclonal BLR272L unconjugated Recombinant Antibody
anti-Insulinoma-Associated 1 (INSM1) antibodyINSM1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Insulinoma-Associated 1 (INSM1) (AA 278-518) antibodyINSM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulinoma-Associated 1 (INSM1) (C-Term) antibodyINSM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulinoma-Associated 1 (INSM1) (AA 191-240) antibodyINSM1 适用: 人, 小鼠, 犬, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulinoma-Associated 1 (INSM1) (Middle Region) antibodyINSM1 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Human pancreas or neuroendocrine tumor.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- INSM1 (Insulinoma-Associated 1 (INSM1))
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别名
- INSM1
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背景
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IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1
Human pancreas or neuroendocrine tumor.
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分子量
- 58kDa
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基因ID
- 3642, 89584
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UniProt
- Q01101
抗原
-
