MDM4-binding Protein 抗体 (AA 8-490)
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Quick Overview for MDM4-binding Protein 抗体 (AA 8-490) (ABIN7876836)
抗原
See all MDM4-binding Protein (MDM4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 8-490
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原理
- MDMX Antibody / MDM4
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纯化方法
- Antigen affinity purified
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免疫原
- An E.coli-derived human recombinant protein (A8-A490) was used as the immunogen for the MDMX antibody.
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亚型
- IgG
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anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibody
MDM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 2D10F4 unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D11 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 1-490) antibodyMDM4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) antibodyMDM4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3A6 unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, IP, FACS 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) (AA 125-175) antibodyMDM4 适用: 人 WB, IP, FACS 宿主: 兔 Monoclonal BL-3-2F2 unconjugated Recombinant Antibody
anti-Mdm4-binding Protein (MDM4) (AA 130-179) antibodyMDM4 适用: 人, Cow, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (pSer367) antibodyMDM4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mdm4-binding Protein (MDM4) (AA 35-72), (N-Term) antibodyMDM4 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MDMX antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MDMX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))
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别名
- MDMX
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背景
- Protein Mdm4/Mdmx is a protein that in humans is encoded by the MDM4 gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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UniProt
- O15151
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途径
- Cell Division Cycle
抗原
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