SAV1 抗体 (AA 8-320)
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Quick Overview for SAV1 抗体 (AA 8-320) (ABIN7876818)
抗原
See all SAV1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 8-320
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原理
- SAV1 Antibody / Protein salvador homolog 1 / WW45
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids K8-H320) was used as the immunogen for the SAV1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the SAV1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SAV1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SAV1 (Salvador Homolog 1 (SAV1))
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别名
- SAV1
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背景
- Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
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UniProt
- Q9H4B6
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途径
- Stem Cell Maintenance
抗原
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