MIB1 抗体 (AA 78-995)
Our Local Distributor
北京 101111
Quick Overview for MIB1 抗体 (AA 78-995) (ABIN7876788)
抗原
See all MIB1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 78-995
-
原理
- Zebrafish Mib1 Antibody / Mind bomb 1
-
纯化方法
- Antigen affinity chromatography
-
免疫原
- E. coli-derived zebrafish Mib1 recombinant protein (amino acids I78-K995) was used as the immunogen for the Zebrafish Mib1 antibody.
-
亚型
- Ig Fraction
-
-
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 6-221) antibody
MIB1 适用: 人, 猴 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6A9C9 unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 5-332) antibodyMIB1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) antibodyKD Validated MIB1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB420 unconjugated Recombinant Antibody
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 13-42), (N-Term) antibodyMIB1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4448 unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 769-1000) antibodyMIB1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 909-1006) antibodyMIB1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 909-1006) antibodyMIB1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) (AA 560-860) antibodyMIB1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) antibodyMIB1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1) antibodyMIB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the Zebrafish Mib1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Zebrafish Mib1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
-
别名
- Mib1
-
背景
-
Mib1, or mind bomb one, is an essential E three ubiquitin ligase that plays a critical role in the regulation of Notch signaling during vertebrate development. In zebrafish, Mib1 is necessary for the proper functioning of the Notch pathway, which controls cell fate decisions, tissue patterning, and the formation of organs such as the brain, spinal cord, and somites.
Mib1 functions by promoting the ubiquitination and endocytosis of Delta ligands on the surface of signal sending cells. This endocytosis is required for activation of the Notch receptor in neighboring cells. In zebrafish embryos, Mib1 is expressed in regions undergoing active cell differentiation and tissue segmentation. Loss of Mib1 function leads to widespread defects in neurogenesis, somitogenesis, and other Notch dependent processes.
Studies using zebrafish mutants have shown that Mib1 is critical for lateral inhibition in the developing nervous system, the formation of the segmented body axis, and the maintenance of progenitor pools in various tissues. Because of its conserved function across vertebrates, zebrafish Mib1 is a widely used model for understanding the molecular mechanisms of Notch signaling and its role in development and disease.
Zebrafish Mib1 is especially valuable in genetic and pharmacological screens aimed at identifying modifiers of the Notch pathway and related developmental disorders.
-
UniProt
- Q804S5
-
途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
-
