IL12RB2 抗体 (AA 756-783)
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Quick Overview for IL12RB2 抗体 (AA 756-783) (ABIN7876736)
抗原
See all IL12RB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 756-783
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原理
- IL12RB2 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 756-783 from the human protein was used as the immunogen for the IL12RB2 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the IL12RB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the IL12RB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
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别名
- IL12RB2
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背景
- The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
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UniProt
- Q99665
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途径
- JAK/STAT Signaling
抗原
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