PPARD 抗体 (AA 72-146)
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Quick Overview for PPARD 抗体 (AA 72-146) (ABIN7876624)
抗原
See all PPARD 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 72-146
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原理
- PPAR delta Antibody / PPARD (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 72-146) from the human protein was used as the immunogen for the PPAR delta antibody.
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亚型
- IgG2a
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应用备注
- Optimal dilution of the PPAR delta antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the PPAR delta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
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别名
- PPAR delta
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背景
- Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARa, PPARb (also designated PPARd and PPARdelta) and PPARg, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARa is abundant in primary hepatocytes, where it regulates the expression of proteins involved in fatty acid metabolism. PPARb is the most widely distributed subtype and is often expressed at high levels. PPARg is predominantly seen in adipose tissue, where it plays a critical role in regulating adipocyte differentiation. Interestingly, both the orphan nuclear hormone receptor LXRa and thyroid receptor (TR) have been shown to act as antagonists of PPARa/ RXRa binding to PPREs.
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UniProt
- Q03181
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation
抗原
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