MIB2 抗体 (AA 71-572)
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Quick Overview for MIB2 抗体 (AA 71-572) (ABIN7876609)
抗原
See all MIB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 71-572
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原理
- MIB2 Antibody / Mindbomb 2
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids A71-I572) was used as the immunogen for the MIB2 antibody.
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亚型
- IgG
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anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 546-784) antibody
MIB2 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 687-930) antibodyMIB2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 381-480) antibodyMIB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B5 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 407-663) antibodyMIB2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 216-249) antibodyMIB2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB54754 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 381-480) antibodyMIB2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 1-128) antibodyMIB2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 300-580) antibodyMIB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MIB2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MIB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))
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别名
- MIB2
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背景
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MIB2 (Mindbomb 2) is a RING-type E3 ubiquitin ligase that regulates membrane protein turnover and signal transduction, most notably within the Notch pathway. By catalyzing ubiquitination of Delta-like ligands, MIB2 promotes their endocytosis and activation competence, ensuring proper receptor engagement and downstream transcriptional responses. Through these activities, MIB2 helps coordinate cellâ€""cell communication during development and tissue homeostasis.
Beyond canonical Notch signaling, MIB2 has been implicated in cytoskeletal organization and broader ubiquitin-mediated quality control. Altered MIB2 expression or activity can influence cell fate decisions, neural and immune system function, and tumor biology, where disrupted ligand trafficking and signaling balance contribute to disease phenotypes. Its functional overlap and divergence relative to the paralog MIB1 highlight MIB2 as a distinct regulator with tissue- and context-specific roles.
The MIB2 antibody enables specific detection of endogenous MIB2 in cells and tissues for applications including western blot, immunofluorescence, and immunohistochemistry. Researchers use the MIB2 antibody to quantify expression, assess subcellular localization at membranes and endosomes, and monitor pathway modulation under genetic or pharmacologic perturbations. With high specificity and consistent performance, the MIB2 antibody supports studies of ubiquitin signaling, Notch pathway regulation, and disease mechanisms.
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UniProt
- Q96AX9
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途径
- Notch Signaling
抗原
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