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CD276 抗体 (AA 7-3, AA 100-300)

The 小鼠 单克隆 anti-CD276 antibody is suitable to detect CD276 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7876482
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CD276 抗体 (AA 7-3, AA 100-300) (ABIN7876482)

抗原

See all CD276 抗体
CD276

适用

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宿主

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  • 19
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小鼠

克隆类型

  • 100
  • 47
  • 1
单克隆

标记

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This CD276 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

B7H3-4313
  • 抗原表位

    • 19
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    AA 7-3, AA 100-300

    原理

    B7-H3 Antibody / CD276 (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the B7-H3 antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the B7-H3 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    CD276

    别名

    B7-H3

    背景

    T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory molecules. One such molecule, B7-H3 (B7-homolog 3, also designated B7RP-2) belongs to the B7 immunoglobulin superfamily. Soluble B7-H3 binds a putative receptor on activated T-cells that is distinct from CD28, CTLA-4, ICOS and PD-1. Widely expressed on nonlymphoid tissues, B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells. The ability of B7-H3 to stimulate Th1 and cytotoxic-T cell responses suggest that it may have antitumor activity. B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, implicating B7-H3 as a potential therapeutic tool.

    UniProt

    Q5ZPR3

    途径

    Cancer Immune Checkpoints
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