CD276 抗体 (AA 7-3)
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北京 101111
Quick Overview for CD276 抗体 (AA 7-3) (ABIN7876479)
抗原
See all CD276 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 7-3
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原理
- B7-H3 Antibody / CD276
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纯化方法
- Protein G affinity
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免疫原
- Recombinant human protein was used as the immunogen for the B7-H3 antibody.
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亚型
- IgG1, kappa
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应用备注
- The stated application concentrations are suggested starting points. Titration of the B7-H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CD276
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别名
- B7-H3
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背景
- May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
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UniProt
- Q5ZPR3
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途径
- Cancer Immune Checkpoints
抗原
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