Chordin 抗体 (AA 69-940)
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Quick Overview for Chordin 抗体 (AA 69-940) (ABIN7876452)
抗原
See all Chordin (CHRD) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 69-940
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原理
- Zebrafish Chordin Antibody / Chd / Chrd
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Chordin recombinant protein (amino acids H69-H940) was used as the immunogen for the Zebrafish Chordin antibody.
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亚型
- Ig Fraction
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anti-Chordin (CHRD) (AA 700-918) antibody
CHRD 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) (AA 422-635) antibodyCHRD 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) antibodyCHRD 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) (AA 686-955) antibodyCHRD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) antibodyCHRD 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) (C-Term) antibodyCHRD 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) (AA 137-167), (N-Term) antibodyCHRD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chordin (CHRD) (AA 926-955), (C-Term) antibodyCHRD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Chordin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Chordin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Chordin (CHRD)
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别名
- Chordin
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背景
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Chordin (also called Chd, Chrd) is a secreted glycoprotein that plays a central role in early embryonic development by antagonizing Bone Morphogenetic Protein (BMP) signaling. In zebrafish (Danio rerio), Chordin is a key dorsalizing factor that helps establish the dorsoventral axis during gastrulation, contributing to proper tissue patterning and organogenesis.
Chordin functions by binding directly to BMP ligands (such as Bmp2 and Bmp4), preventing them from interacting with their receptors and thereby inhibiting BMP signaling activity in dorsal regions of the embryo. The zebrafish chordin gene is expressed in the organizer region (shield) during early development, and its activity is essential for the formation of dorsal structures such as the notochord, neural plate, and somites.
Loss-of-function mutations in chordin lead to ventralized phenotypes, while overexpression can result in dorsalization, underscoring its importance as a morphogen regulator. Due to its highly conserved function across vertebrates, zebrafish Chordin is widely used in studies of axis specification, morphogen gradients, neural induction, and BMP pathway modulation.
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UniProt
- O57472
抗原
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