ROCK2 抗体 (AA 652-909)
Our Local Distributor
北京 101111
Quick Overview for ROCK2 抗体 (AA 652-909) (ABIN7876320)
抗原
See all ROCK2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 652-909
-
原理
- ROCK2 Antibody
-
纯化方法
- Affinity purified
-
免疫原
- A human recombinant partial protein (amino acids E652-D909) was used as the immunogen for the ROCK2 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the ROCK2 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the ROCK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))
-
别名
- ROCK2
-
背景
- Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.
-
UniProt
- O75116
-
途径
- Microtubule Dynamics, WNT signaling, Tube Formation
抗原
-