Retinoblastoma Protein (Rb) 抗体 (AA 600-620)
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Quick Overview for Retinoblastoma Protein (Rb) 抗体 (AA 600-620) (ABIN7876000)
抗原
See all Retinoblastoma Protein (Rb) (Rb Protein) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 600-620
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原理
- Retinoblastoma Antibody / Rb1
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 600-620 from the human protein was used as the immunogen for the Retinoblastoma antibody.
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亚型
- Ig Fraction
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anti-Retinoblastoma Protein (Rb Protein) (AA 858-886) antibody
Rb Protein 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 586-615) antibodyRb Protein 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer811) antibodyRb Protein 适用: 人 IHC, ELISA, IF, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibodyKD Validated Rb Protein 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3375 unconjugated Recombinant Antibody
anti-Retinoblastoma Protein (Rb Protein) (pSer807) antibodyKD Validated Rb Protein 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3245 unconjugated Recombinant Antibody
anti-Retinoblastoma Protein (Rb Protein) (Cleavage Site) antibodyRb Protein 适用: 人, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal 172C1094 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer788) antibodyRb Protein 适用: 人 IHC, ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibodyRb Protein 适用: 人 IHC, ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (pSer608) antibodyRb Protein 适用: 人 IHC, ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibodyRb Protein 适用: 人, 小鼠, 大鼠, Cow, 犬, 猴, Pig, Bat, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Retinoblastoma antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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别名
- Retinoblastoma
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背景
- Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
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UniProt
- P06400
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途径
- Mitotic G1-G1/S Phases
抗原
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