APOH 抗体 (AA 592-689)
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Quick Overview for APOH 抗体 (AA 592-689) (ABIN7875928)
抗原
See all APOH 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 592-689
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原理
- APOH Antibody / Apolipoprotein H
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纯化方法
- Protein A/G affinity
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免疫原
- A human recombinant Apolipoprotein H protein fragment (within amino acids 592-689) was used as the immunogen for the APOH antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the APOH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the APOH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))
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别名
- APOH
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背景
- Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.
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UniProt
- P02749
抗原
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