PREX2 抗体 (AA 582-1094)
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Quick Overview for PREX2 抗体 (AA 582-1094) (ABIN7875864)
抗原
See all PREX2 (DEPDC2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 582-1094
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原理
- PREX2 Antibody / DEPDC2
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids D582-Q1094) was used as the immunogen for the PREX2 antibody.
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亚型
- IgG
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anti-DEP Domain Containing 2 (DEPDC2) (AA 1417-1592) antibody
DEPDC2 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (AA 1-979) antibodyDEPDC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (AA 582-1094) antibodyDEPDC2 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-DEP Domain Containing 2 (DEPDC2) (N-Term) antibodyDEPDC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PREX2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PREX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))
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别名
- PREX2
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背景
- Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, also called DEPDC2 (DEP domain-containing protein 2), is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.
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UniProt
- Q70Z35
抗原
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