Dysferlin 抗体 (AA 51-747)
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Quick Overview for Dysferlin 抗体 (AA 51-747) (ABIN7875526)
抗原
See all Dysferlin (DYSF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-747
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原理
- DYSF Antibody / Dysferlin
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纯化方法
- Affinity purified
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免疫原
- An E. coli-derived human protein (amino acids E51-H747) was used as the immunogen for the DYSF antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the DYSF antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DYSF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Dysferlin (DYSF)
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别名
- DYSF
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背景
- Dysferlin also known as dystrophy-associated fer-1-like protein is a protein that in humans is encoded by the DYSF gene. The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants.
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UniProt
- O75923
抗原
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