KIF3A 抗体 (AA 486-701)
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Quick Overview for KIF3A 抗体 (AA 486-701) (ABIN7875231)
抗原
See all KIF3A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 486-701
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原理
- Zebrafish Kif3a Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Kif3a recombinant protein (amino acids D486-Q701) was used as the immunogen for the Zebrafish Kif3a antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Kif3a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Kif3a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- KIF3A (Kinesin Family Member 3A (KIF3A))
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别名
- Kif3a
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背景
- Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the plus ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.
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UniProt
- E9QB71
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途径
- Hedgehog Signaling
抗原
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