TYRO3 抗体 (AA 48-882)
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Quick Overview for TYRO3 抗体 (AA 48-882) (ABIN7875218)
抗原
See all TYRO3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-882
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原理
- TYRO3 Antibody / TYRO3 protein tyrosine kinase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TYRO3 recombinant protein (Position: A48-Q882) was used as the immunogen for the TYRO3 antibody.
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亚型
- IgG
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anti-TYRO3 Protein Tyrosine Kinase (TYRO3) antibody
TYRO3 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal 5B4 unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) antibodyTYRO3 适用: 人 WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) antibodyTYRO3 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal 4C8 unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 50-150) antibodyTYRO3 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 4F6 unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 728-873) antibodyTYRO3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 842-873), (C-Term) antibodyTYRO3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1489 unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 346-361), (Extracellular) antibodyTYRO3 适用: 小鼠 WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 1-890) antibodyTYRO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) antibodyTYRO3 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-TYRO3 Protein Tyrosine Kinase (TYRO3) (AA 138-321) antibodyTYRO3 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 6D6F10 unconjugated
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应用备注
- Optimal dilution of the TYRO3 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TYRO3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))
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别名
- TYRO3
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背景
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TYRO3 antibody detects TYRO3 protein tyrosine kinase, encoded by the TYRO3 gene on chromosome 15q15.1. TYRO3 antibody is widely applied in studies of receptor tyrosine kinase signaling, cell survival, and immune regulation. TYRO3 is part of the TAM receptor family, which also includes AXL and MERTK. It functions as a receptor for ligands such as Gas6 and Protein S, activating intracellular signaling pathways that regulate cell proliferation, survival, phagocytosis, and immune modulation. Expression is broad, with high levels in brain, reproductive tissues, and immune cells.
Structurally, TYRO3 is a type I transmembrane protein with extracellular immunoglobulin-like domains that mediate ligand binding, followed by fibronectin type III domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Upon ligand binding, TYRO3 undergoes autophosphorylation and recruits signaling molecules including PI3K, GRB2, and SRC family kinases. These interactions activate pathways such as PI3K-AKT and MAPK, promoting survival and proliferation.
Functionally, TYRO3 contributes to tissue homeostasis by supporting cell survival, clearance of apoptotic cells, and regulation of immune responses. In neurons, it promotes survival and myelination. In immune cells, TYRO3 suppresses excessive inflammatory responses, maintaining tolerance and preventing autoimmunity. In reproductive biology, it supports spermatogenesis and fertility. Knockout models show neurological defects, immune dysregulation, and reproductive impairment. Researchers use TYRO3 antibody to study tyrosine kinase signaling, neural survival, and immune regulation.
Clinically, TYRO3 dysregulation is linked to cancer, autoimmune disease, and neurodegeneration. Overexpression of TYRO3 supports survival and drug resistance in cancers such as melanoma, glioblastoma, and breast cancer. In contrast, reduced TYRO3 signaling contributes to multiple sclerosis and lupus, where clearance of apoptotic cells is impaired. TYRO3 also has neuroprotective roles, with reduced activity associated with Parkinson's and Alzheimer's disease. NSJ Bioreagents offers TYRO3 antibody as a validated reagent for oncology, neurobiology, and immunology research.
Experimentally, TYRO3 antibody is applied in western blotting to detect the ~140 kDa protein, in immunohistochemistry to assess expression in tumors or brain tissue, and in immunofluorescence microscopy to study receptor localization. Immunoprecipitation with TYRO3 antibody reveals signaling complexes with ligands and kinases, providing insight into downstream pathways. -
UniProt
- Q06418
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途径
- RTK signaling
抗原
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