SCARB2 抗体 (AA 48-357)
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Quick Overview for SCARB2 抗体 (AA 48-357) (ABIN7875206)
抗原
See all SCARB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-357
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原理
- SR-BII Antibody / SCARB2 / LIMPII
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids E48-H357) was used as the immunogen for the SR-BII antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the SR-BII antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SR-BII antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))
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别名
- SR-BII
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背景
- Lysosomal integral membrane protein 2 (LIMP-2), also called Scavenger receptor class B member 2, is a protein that in humans is encoded by the SCARB2 gene. The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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UniProt
- Q14108
抗原
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