Cullin 1 抗体 (AA 436-777)
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Quick Overview for Cullin 1 抗体 (AA 436-777) (ABIN7874985)
抗原
See all Cullin 1 (CUL1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 436-777
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原理
- Zebrafish Cul1 Antibody / Cul1a / Cul1b / Cullin 1
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Cul1a/b recombinant protein (amino acids K436-A777) was used as the immunogen for the Zebrafish Cul1 antibody. This antibody will detect the a and b isoforms of Cul1.
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亚型
- Ig Fraction
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anti-Cullin 1 (CUL1) (AA 500-776) antibody
CUL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) antibodyKD Validated CUL1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1555 unconjugated Recombinant Antibody
anti-Cullin 1 (CUL1) antibodyCUL1 适用: 人, 小鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) antibodyCUL1 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) (AA 1-250) antibodyCUL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) (AA 1-776) antibodyCUL1 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) antibodyCUL1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) (C-Term) antibodyCUL1 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cullin 1 (CUL1) (C-Term) antibodyCUL1 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Cullin 1 (CUL1) (C-Term) antibodyCUL1 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Cul1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Cul1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Cullin 1 (CUL1)
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别名
- Cul1
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背景
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Cullin 1 (Cul1) is a core component of the SCF (SKP1â€""Cullinâ€""F-box) E3 ubiquitin ligase complex, which plays a crucial role in regulating protein turnover via the ubiquitin-proteasome system. In zebrafish (Danio rerio), Cul1 is highly conserved and functionally analogous to its mammalian counterpart, mediating ubiquitination and subsequent proteasomal degradation of key regulatory proteins involved in cell cycle progression, signal transduction, and developmental processes.
Cul1 functions as a scaffold protein, linking the SKP1 adaptor and the Rbx1 RING-finger protein, enabling the recruitment of specific F-box proteins that confer substrate specificity. Zebrafish cul1 expression is detected during early embryogenesis, particularly in proliferative tissues, reflecting its essential role in controlling cell division and differentiation during development.
Functional studies in zebrafish have shown that loss of Cul1 activity can disrupt cell cycle control, leading to developmental defects and altered cell proliferation. Its evolutionary conservation and essential cellular functions make zebrafish Cul1 a valuable model for studying ubiquitin-mediated regulation in vertebrate development and disease models.
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UniProt
- Q6NYS3
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途径
- Cell Division Cycle, Hedgehog Signaling, Mitotic G1-G1/S Phases, Regulation of Cell Size
抗原
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