GLUD1 抗体 (AA 40-539)
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Quick Overview for GLUD1 抗体 (AA 40-539) (ABIN7874704)
抗原
See all GLUD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 40-539
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原理
- Zebrafish Glud1 Antibody / Glud1a / Glud1b / Glutamate dehydrogenase
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Glud1a/b recombinant protein (amino acids S40-A539) was used as the immunogen for the Zebrafish Glud1 antibody. This antibody will detect the a and b isoforms.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Glud1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Glud1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))
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别名
- Glud1
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背景
- This gene encodes Glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
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UniProt
- Q6NZ29
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途径
- Positive Regulation of Peptide Hormone Secretion, Warburg Effect
抗原
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