MADD 抗体 (AA 4-335)
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Quick Overview for MADD 抗体 (AA 4-335) (ABIN7874673)
抗原
See all MADD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-335
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原理
- Zebrafish Madd Antibody / MAP kinase-activating death domain protein
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Madd recombinant protein (amino acids K4-Y335) was used as the immunogen for the Zebrafish Madd antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Madd antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Madd antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MADD (MAP-Kinase Activating Death Domain (MADD))
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别名
- Madd
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背景
- MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.
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途径
- Caspase Cascade in Apoptosis
抗原
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