MSH6 抗体 (AA 374-540)
Our Local Distributor
北京 101111
Quick Overview for MSH6 抗体 (AA 374-540) (ABIN7874455)
抗原
See all MSH6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 374-540
-
原理
- MSH6 Antibody
-
纯化方法
- Protein G affinity chromatography
-
免疫原
- A recombinant human MSH6 protein fragment within amino acids 374-540 was used as the immunogen for the MSH6 antibody.
-
亚型
- IgG2b, kappa
-
-
-
-
应用备注
-
Optimal dilution of the MSH6 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.2 mg/mL
-
缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store the MSH6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
-
-
- MSH6 (MutS Homolog 6 (E. Coli) (MSH6))
-
别名
- MSH6
-
背景
- The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
-
UniProt
- P52701
-
途径
- DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
-