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Recombinant MSH6 抗体 (AA 374-540)

This 小鼠 单克隆 antibody specifically detects MSH6 in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7874441
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Recombinant MSH6 抗体 (AA 374-540) (ABIN7874441)

抗原

See all MSH6 抗体
MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

抗体类型

Recombinant Antibody

适用

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宿主

  • 119
  • 84
  • 3
小鼠

克隆类型

  • 155
  • 50
  • 1
单克隆

标记

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  • 1
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This MSH6 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RMSH6-6846
  • 抗原表位

    • 67
    • 15
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    • 1
    AA 374-540

    原理

    Recombinant MSH6 Antibody

    纯化方法

    Protein A/G affinity

    免疫原

    A portion of amino acids 374-540 was used as the immunogen for the recombinant MSH6 antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the recombinant MSH6 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the recombinant MSH6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

    别名

    MSH6

    背景

    The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.

    UniProt

    P52701

    途径

    DNA Damage Repair, Chromatin Binding, Production of Molecular Mediator of Immune Response
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