Angiopoietin 2 抗体 (AA 357-404)
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Quick Overview for Angiopoietin 2 抗体 (AA 357-404) (ABIN7874276)
抗原
See all Angiopoietin 2 (ANGPT2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 357-404
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原理
- ANGPT2 Antibody / Angiopoietin-2 / ANG2
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纯化方法
- Affinity purified
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免疫原
- Recombinant human protein (amino acids N357-K404) was used as the immunogen for the ANGPT2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the ANGPT2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ANGPT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Angiopoietin 2 (ANGPT2)
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别名
- ANGPT2
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背景
- ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.
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UniProt
- O15123
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途径
- RTK signaling
抗原
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