PAPPA 抗体 (AA 351-523)
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北京 101111
Quick Overview for PAPPA 抗体 (AA 351-523) (ABIN7874253)
抗原
See all PAPPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 351-523
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原理
- PAPPA Antibody / Pappalysin-1
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纯化方法
- Protein G affinity chromatography
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免疫原
- A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.
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亚型
- IgG2b, kappa
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应用备注
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The stated application concentrations are suggested starting points. Titration of the PAPPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
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别名
- PAPPA
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背景
- The PAPPA gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [RefSeq]
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UniProt
- Q13219
抗原
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